The primary objective of Vertical Spokes is to identify and develop the most promising candidate targets for RNA-based drugs across the following five key areas of human diseases: genetic diseases, cancer, metabolic and cardiovascular conditions, neurodegenerative disorders, and inflammatory/infectious ailments.
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Goals of the project The fundamental science questions The therapeutic applications ProgramLed by University of Modena and Reggio Emilia, Spoke 1 coordinates activities related to RNA-based technologies and gene therapy in Genetic Diseases.
Led by Sapienza University of Rome, Spoke 2 coordinates activities related to RNA-based technologies and gene therapy in Cancer.
Led by the Italian Institute of Technology, Spoke 3 coordinates activities related to RNA-based technologies and gene therapy in Neurodegeneration.
Led by University of Padua, Spoke 4 coordinates activities related to RNA-based technologies and gene therapy in Metabolic and Cardiovascular Diseases.
Led by University of Siena, Spoke 5 coordinates activities related to RNA-based technologies and gene therapy in Infectious and Inflammatory Diseases.