National Center for Gene Therapy

and Drugs based on RNA Technology

 

By sharing knowledge and resources, we can accelerate the development of cutting-edge RNA and gene therapies

The research program aims to deepen understanding of disease mechanisms and develop new therapies, enhancing healthcare efficiency and sustainability within a knowledge-based economy.

The National Center hosts numerous projects organized through a Hub and Spoke model: Vertical Spokes identify promising targets for RNA-based drugs, while Horizontal Spokes develop and share technologies for designing, producing, and delivering gene and RNA therapies. Their integration will advance RNA pharmacology, gene therapy, and precision medicine. The Center also promotes cutting-edge infrastructures, high-tech entrepreneurship, and education.

What is RNA and gene therapy?

 

As an interdisciplinary field, which includes molecular biology, genetics, biotechnology, pharmaceutics, pharmacology, and clinical medicine, research activities based on ribonucleic acid (RNA) and gene therapy aim to create a step change in healthcare through treatments that are:

  • Personalized – based on the molecular profile of a specific individual (genetic – DNA or transcriptomic – RNA)
  • Precise – targeting the molecular roots of a disease (e.g. a neurodegenerative pathway), thus minimizing effects on physiological mechanisms
  • Flexible – adapting to the changing pattern of disease (e.g. a virus or a tumor becoming therapy-resistant)
  • Variably lasting – duration tunable from days (e.g. antigen production caused by mRNA vaccines) to lifelong results (e.g. through DNA modification).
PharmaTech Academy

PharmaTech Academy

PharmaTech Academy is a training initiative of the National Center led by the University of Napoli Federico II, Department of Pharmacy. Its main objective is to train highly qualified professionals to operate across all phases of RNA-based drug development, thanks to a practical and professional educational approach based on the concept of “learning by doing”.

Built on a close collaboration between universities and private companies participating in the National Center, the Academy aims to expand the skills acquired during degree programs by offering hands-on experience and direct contact with the pharmaceutical industry, thus contributing to the creation of specialized figures in the field of RNA gene therapy in Italy.

National PhD

The RNA Therapeutics and Gene Therapy National PhD program aims to train highly qualified researchers with the scientific expertise and autonomous research skills needed to address the challenges of RNA-based drugs and gene therapy.

As a comprehensive three-year doctoral degree program, guided by the Department of Pharmacy at the University of Naples Federico II, the program involves ten universities and two research centers across Italy.

RNA Placement Program

The National Center for RNA and Gene Therapy has launched the RNA Placement Program, a platform developed by Fondazione Emblema to support PhD graduates and researchers currently involved in the National Center eager to start their careers. The Program includes coaching sessions, career orientation, and meetings with HR managers from companies seeking to develop human capital with a selected group of highly qualified personnel. A dedicated section focuses on start-up and entrepreneurship activities, featuring a Contamination Lab for exploring key aspects of innovation and research. The initiative concludes with an online Career Day and a Club Deal with potential investors. Please visit the dedicated RNA Placement Program portal for more details.