National Center secures PN RIC 2021–2027 funding to strengthen Italy's leadership in gene therapy and RNA technologies

31 July 2026, Padua – The National Center for Gene Therapy and Drugs based on RNA Technology has secured funding under the Ministry of University and Research’s National Programme for Research, Innovation and Competitiveness for the Green and Digital Transition (PN RIC) 2021–2027, ensuring the continuation and consolidation of some of the most promising initiatives launched during its initial National Recovery and Resilience Plan (NRRP) funding phase.

Submitted in July 2025 in response to the Ministry’s call “Support for initiatives to strengthen strategic supply chains, to network forms of aggregation between research actors and to develop skills for smart specialization, industrial transition and entrepreneurship” (Directorial Decree No. 307 of 18 March 2025), the successful proposals will ensure that key research infrastructures, innovation activities and advanced training program launched through the National Center continue to grow beyond the initial NRRP funding period.

The awarded projects, each with an initial duration of 30 months from 19 June 2026, reinforce the National Center’s mission to accelerate the development of gene therapies and RNA-based medicines, strengthen technology transfer, foster collaboration between academia and industry, and build the highly specialized workforce needed to support the next generation of advanced therapies.

Advancing Translational Research

The RNA-NEXT project (Integrated Development of RNA Drugs and Gene Therapy: From Molecular Design to GMP Production and Clinical Validation) will strengthen the translational pipeline for RNA therapeutics and innovative gene therapies by integrating advanced research, regulated GMP and GLP manufacturing, innovative preclinical models, artificial intelligence and machine learning.

The project aims to advance RNA-based technologies from Technology Readiness Levels (TRL) 3-4 to TRL 6-7, enabling their progression towards industrial development and clinical application. It will also establish interoperable technological platforms, train highly specialized professionals, and develop strategies to accelerate technology transfer.

Coordinated through a broad national partnership, RNA-NEXT brings together the National Center Foundation, the Universities of Palermo, Naples Federico II, Campania Luigi Vanvitelli and Bari, the National Research Council (CNR), BIOGEM, Dompé Farmaceutici, P.B.L., Scylla Biotech and Tecno-Bios.

Strengthening Innovation and Entrepreneurship

The INNOVA-RNA project (Integrated Ecosystem for Research, Production and Business Incubation in RNA Therapies) extends the National Center’s innovation ecosystem through the creation of a sustainable Innovation Hub dedicated to RNA therapeutics.

By combining advanced research infrastructures with business services, mentoring, incubation programs and flexible access models for SMEs, start-ups and spin-offs, the project aims to accelerate the translation of scientific discoveries into commercial innovation.

At the core of the initiative is IDEAS-RNA, which aims at supporting entrepreneurship and facilitate collaboration between researchers, innovators and industry partners. The project involves the National Center Foundation, the Universities of Palermo, Naples Federico II and Bari together with Dompé Farmaceutici, BIOGEM, Genus Biotech, Materias, P.B.L. and Scylla Biotech.

Investing in the Next Generation of Talent

Building on the success of the PharmaTech Academy, the Advanced PharmaTech Academy project will strengthen technical, scientific, digital, regulatory and entrepreneurial skills across the pharmaceutical and biotechnology sectors.

Using the Academy’s established infrastructure—including its PharmaTech-XR multimedia classrooms and immersive laboratories—the initiative will deliver advanced, flexible and customizable training programs that support industrial innovation, digital transformation and environmental sustainability. The project is designed as a scalable model for lifelong learning in the life sciences sector and is delivered through a partnership between the National Center Foundation, the University of Naples Federico II, P.B.L. and Materias.

Together, the three projects demonstrate the National Center’s commitment to ensuring that the investments made under the NRRP continue to generate scientific excellence, technological innovation, industrial competitiveness and highly skilled human capital, strengthening Italy’s position as a leader in advanced therapies.

Strengthening Collaborations: The IMPACT Initiative

In addition to these awards, the National Center is also a co-proponent with HEAL Italia in the jointly funded IMPACT initiative, a 27-month program dedicated to strengthening strategic research value chains in precision medicine. Through the complementary IMPACT-112 and IMPACT-113b projects, the initiative will support the development and validation of innovative technologies for personalized medicine, promote technology transfer, and accelerate the translation of research results into clinical and industrial applications. Bringing together the two NRRP Hubs with universities, research institutes and SMEs across Southern Italy, the program aims to improve access to advanced therapies for cancer and cardio metabolic diseases while reinforcing collaboration throughout Italy’s health innovation ecosystem.

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