RNA - Genetherapys
Who we are


CNR Researchers from 9 institutes in 6 different Italian regions, have highly qualified and internationally recognized expertise in the RNA field, in particular non-coding RNA. Leveraging their competences in the analysis of lncRNA in cancer, the role of ncRNA in the DNA damage response and regulation of translation and of alternative splicing, researchers will develop new tools and methods to specifically target pathological cells. In addition, they will provide important skills for both qualitative and quantitative manipulation of target RNAs with PNA, aptamers and RNA editing approaches.

Silvo Conticello
Principal Investigator

IFC

Angela Membrino
PhD student

IFC

Pietro Laneve
Researcher

IBPM

Pierpaolo Ceci
Researcher

IBPM

Gianluca Cestra
Researcher

IBPM

Giuseppe Biamonti
Research Manager

IGM

Fabrizio D’Adda di Fagagna
Research Manager

IGM

Sofia Francia
Researcher

IGM

Claudia Ghigna
Researcher

IGM

Alessandra Montecucco
Researcher

IGM

Sara Tavella
Researcher RTD

IGM

Roberto Improta
Research Manager

IBB

Maria Romano
Researcher

IBB

Emanuela Iaccarino
Fixed-term scientist

IBB

Michele Saviano
Research Director

IC

Martina Rotondo
PhD Student

IC


The UNIBA team holds a long-standing experience in methods and technologies to profile epitranscriptome modifications, with emphasis on not transient RNA changes referred to as RNA editing events. Currently developing site-directed RNA editing approaches to correct pathological point mutations, UNIBA will harness the power of endogenous ADAR enzymes for Adenosine-to-Inosine editing.

Anna Maria D'erchia
Associate Professor

Bruno Fosso
Researcher

Guglielmina Chimienti
Researcher

Ernesto Picardi
Full Professor

Andrea Gerbino
Associate Professor

Francesco Pisani
Associate Professor

Giuseppe Procino
Full Professor

Vito Pesce
Associate Professor

Elena Orecchini
Researcher RTD-A

Roberta De Zio
Researcher RTD-A

Petronella Frugis
Phd student

Davide Capuano
Phd student


The UNIBO team has a strong record in drug discovery and drug development. They are developing new technologies for the stereoselective synthesis of oligonucleotides to study the backbone effect on protein binding. This topic is critical for drug distribution, stabilization, and efficacy. They will also investigate PNA and conjugates in collaboration with CNR Naples. UNIBO will also focus on the design of small molecules for RNA degradation, RIBOnuclease Targeting Chimeras RIBOTACs.

Angela Abruzzo
Researcher RTD

Dipartimento di Farmacia e Biotecnologie – FABIT

Maria Laura Bolognesi
Full professor

Dipartimento di Farmacia e Biotecnologie – FABIT

Walter Cabri
Full professor

Dipartimento Chimica “Giacomo Ciamician” – CHIM

Federico Falchi
Researcher RTD

Dipartimento Chimica “Giacomo Ciamician” – CHIM

Valentina Marassi
Researcher RTD

Dipartimento Chimica “Giacomo Ciamician” – CHIM

Stefano Masiero
Associate professor

Dipartimento Chimica “Giacomo Ciamician” – CHIM

Marinella Roberti
Associate professor

Dipartimento di Farmacia e Biotecnologie – FABIT

Alessandra Tolomelli
Associate professor

Dipartimento Chimica “Giacomo Ciamician” – CHIM

Lucia Ferrazzano
Researcher RTD-A

Dipartimento Chimica “Giacomo Ciamician” – CHIM

Greta Bagnolini
Research Fellow

Dipartimento di Farmacia e Biotecnologie – FABIT

Federico Sdei
Phd student

Dipartimento di Farmacia e Biotecnologie – FABIT

Leonardo Rapisarda
Phd student

Dipartimento Chimica “Giacomo Ciamician” – CHIM


IIT participants have consolidated experience in the use of high-throughput -omics technologies to RNA biology. With the knowledge of state-of-the-art short-read sequencing, and recently developed third-generation sequencing by Nanopore, IIT develops ad hoc tools for their application to human samples for disease and clinical research. They will develop an innovative optical microscopy platform to generate the visualize and quantify efficacy of RNA therapeutics in live cells

Andrea Armirotti
Technologist - Facility Coordinator

Salvatore Antonio Bianchi
Senior Technician

Paolo Bianchini
Technologist

Ottavio Croci
Post-doc Researcher

Alberto Diaspro
Senior Researcher - Principal Investigator

Mattia Donato
Technician

Matteo Jacopo Luca Nicolo Marzi
Technologist

Francesco Nicassio
Senior Researcher Tenured - Principal Investigator

Valter Tucci
Senior Researcher Tenured - Principal Investigator

Giuseppe Vicidomini
Senior Researcher Tenured - Principal Investigator


UNINA participants have consolidated expertise in the identification, characterization, and optimization of RNA aptamersas therapeutics and drug carriers in the form of aptamer-drug conjugates/complexes. Moreover, UNINA brings their expertise in mRNA synthesis and optimization for gene therapy and genetic vaccine applications.

Angela Amoresano
Full professor

Dipartimento di Scienze Chimiche

Nicola Borbone
Associate professor

Dipartimento di Farmacia

Gerolama Condorelli
Full professor

Dipartimento di Medicina Molecolare e Biotecnologie Mediche

Aldo Galeone
Full professor

Dipartimento di Farmacia

Concetta Giancola
Full professor

Dipartimento di Farmacia

Daniela Montesarchio
Full professor

Dipartimento di Scienze Chimiche

Alfredo Nicosia
Full professor

Dipartimento di Medicina Molecolare e Biotecnologie Mediche

Emanuele Sasso
Researcher RTD-A

Dipartimento di Medicina Molecolare e Biotecnologie Mediche

Nicola Zambrano
Full professor

Dipartimento di Medicina Molecolare e Biotecnologie Mediche

Martina Mascolo
Phd student

Dipartimento di Medicina Molecolare e Biotecnologie Mediche

Carla Aliberti
Phd student

Dipartimento di Farmacia

Claudio Savino
Phd student

Dipartimento di Scienze Chimiche


UNIPD participants have extensive expertise in RNA molecular biology and bioinformatics. UNIPD has a record of accomplishment in the development of innovative nucleic acid antisense oligo and in drug delivery to develop new tools for RNA therapeutics, including microRNA and mRNA restoration and long noncoding and circular RNA targeting therapies, with applications to several disorders.

Stefania Bortoluzzi
Associate professor

Dipartimento di Medicina Molecolare

Barbara Gatto
Full professor

Dipartimento di Medicina Molecolare

Claudia Sissi
Full professor

Dipartimento di Medicina Molecolare

Francesca Mastrotto
Associate professor

Dipartimento di Medicina Molecolare

Patrizia Pontisso
Associate professor

Dipartimento di Medicina Molecolare

Renato Zambello
Associate professor

Dipartimento di Medicina Molecolare

Elisabetta Groaz
Researcher RTD

Dipartimento di Medicina Molecolare

Alice Sosic
Researcher RTD

Dipartimento di Medicina Molecolare

Salvatore Silvio Piano
Researcher RTD

Dipartimento di Medicina Molecolare

Antonella Teramo
Researcher RTD

Dipartimento di Medicina Molecolare

Enrico Gaffo
Researcher RTD

Dipartimento di Medicina Molecolare

Michele Ghezzo
Research Fellow

Dipartimento di Medicina Molecolare

Gianluca Zilio
Research Fellow

Dipartimento di Medicina Molecolare

Lara Marcenta
Phd student

Dipartimento di Medicina Molecolare

Beatrice Moras
Phd student

Dipartimento di Medicina Molecolare

Elisa Rampazzo
Phd student

Dipartimento di Medicina Molecolare

Elonora Roncaglia
Phd student

Dipartimento di Medicina Molecolare

Federico Faloci
Phd student

Dipartimento di Medicina Molecolare


Ri.MED participants have consolidated expertise in bioinformatics and machine learning based approaches to transcriptomics data analysis. For Spoke 6, Ri.MED will outline novel algorithms to optimize the anti-sense oligonucleotides designs used as modulators of transcripts expression levels. Their focus will be on aging-related genes, e.g. lamin A/C, involved in Hutchinson-Gilford Progeria Syndrome.

Gaetano Burriesci
Group Leader

Chiara Cipollina
Group Leader in Experimentale Lung Research

Albert Comelli
Senior Scientist in Biomedical Imaging

Claudia Coronnello
Principal Investigator in Advanced Data Analysis

Maria De Rosa
Principal Investigator in Medicinal Chemistry

Roberto Maria Di Gesù
Principal Investigator

Ugo Perricone
Group Leader in Molecular Informatics


UNIROMA2 has a long-lasting experience in the field of DNA/RNA chemistry, DNA/RNA nanotechnology, and DNA/RNA-based biosensors for diagnostic and therapeutic applications. In the frame of Spoke 6, UNIROMA2 are developing synthetic DNA/RNA-based nanoscaffolds and nanostructures that are responsive to molecular and environmental stimuli, which will allow for the targeted delivery of therapeutic drugs or the imaging of specific biomarkers.

Fabiana Arduini
Associate professor

Dipartimento di Scienze e Tecnologie Chimiche

Francesca Cavalieri
Associate professor

Dipartimento di Scienze e Tecnologie Chimiche

Erica Del Grosso
Researcher RTD-A

Dipartimento di Scienze e Tecnologie Chimiche

Andrea Idili
Researcher RTD-A

Dipartimento di Scienze e Tecnologie Chimiche

Laura Micheli
Associate professor

Dipartimento di Scienze e Tecnologie Chimiche

Alessandro Porchetta
Associate professor

Dipartimento di Scienze e Tecnologie Chimiche

Francesco Ricci
Full professor

Dipartimento di Scienze e Tecnologie Chimiche

Simona Ranallo
Researcher RTD-A

Dipartimento di Scienze e Tecnologie Chimiche


UNISI specializes in the computational design and synthesis of light-responsive bio-mimetic molecules. UNISI will focus on the design RNA aptamers (e.g. ribozymes) that hold the biological activity that allows them to be modulated by light, characterized, and used to develop innovative RNA-based therapeutics as well as tools for gene editing.

Massimo Olivucci
Full professor

Dipartimento di Biotecnologie, Chimica e Farmacia

Maurizio Orlandini
Associate professor

Dipartimento di Biotecnologie, Chimica e Farmacia

Marco Paolino
Associate professor

Dipartimento di Biotecnologie, Chimica e Farmacia

Andrea Cappelli
Associate professor

Dipartimento di Biotecnologie, Chimica e Farmacia

Fabrizio Manetti
Full professor

Dipartimento di Biotecnologie, Chimica e Farmacia

Federico Galvagni
Associate professor

Dipartimento di Biotecnologie, Chimica e Farmacia

Giusy Tassone
Researcher RTD-A

Dipartimento di Biotecnologie, Chimica e Farmacia

Alfonso Trezza
Researcher RTD-A

Dipartimento di Biotecnologie, Chimica e Farmacia

Matteo Lami
Research Fellow

Dipartimento di Biotecnologie, Chimica e Farmacia

Xuchun Yang
Research Fellow

Dipartimento di Biotecnologie, Chimica e Farmacia

Riccardo Palombo
Research Fellow

Dipartimento di Biotecnologie, Chimica e Farmacia

Luisa Raucci
Researcher RTD-A

Dipartimento di Biotecnologie, Chimica e Farmacia

Ivanna Gisele Rosenda Juliani Costa
Phd student

Dipartimento di Biotecnologie, Chimica e Farmacia

Leonardo Barneschi
Phd student

Dipartimento di Biotecnologie, Chimica e Farmacia

Jacopo D’Ascenzi
Phd student

Dipartimento di Biotecnologie, Chimica e Farmacia


Built upon its strong record of accomplishment in drug discovery, Takis Biotech will provide significant contributions to the discovery and development of innovative vaccines based on viral vectors and DNA/mRNA platform technology. One of the main assets is the expertise in in vivo electro-gene-transfer (EGT) used for a variety of clinically useful applications, including vaccine development to somatic gene therapy. Concerning its role in Spoke 6, Takis Biotech will develop approaches for the production and delivery of optimized chemokine-expressing mRNAs (i.e CXCL9) to harness the immune system to fight cancer.More specifically, Takis is involved in the optimization of a platform for mRNA therapeutics, including synthesis, structure and delivery. Development of new vectors for the synthesis of mRNA with optimized 5’- and 3’- UTR regions and signal peptide for intra-tumoral expression and secretion of chemokines.

Erika Salvatori
Researcher

Lucia Lione
Researcher

Grazia Vitagliano
Researcher